세로토닌2...수용체

세로토닌 수용체의 종류 및 기능

###5HT-1

---5HT-1A

-기억,학습 저하

-불안, 우울, 공격성 감소

-진통효과 증가,

-[전두엽] 도파민 분비증가

-세로토닌 합성,분비 감소[피드백]

---5HT-1B,D; 혈관수축

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###5HT-2

---2A; [차단 효과없다]환각성 증가, 우울, 불안 감소, 정신분열병의 증상감소

---2B; 심혈관계 기능악화 [폐고혈압위험증가] 감정이입증가

---2C; 도파민분비증가, 아세틸콜린 분비증가, 식욕감소, 정신병증상 감소, 항우울효과증가

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###5HT-3; 구역,구토증가, 불안감소

###5HT-4; 위장관 음식물 흡수증가, 기억,학습능력 증가, 항우울 효과증가,

###5HT-5; Memory consolidation[기억강화]

###5HT-6;인지기능증가, 항우울효과증가

Binding profile of serotonin

Receptor	Ki(nM)[22]	Receptor function[Note 1]
5-HT1 receptor family signals via Gi/o inhibition of adenylyl cyclase.
5-HT1A	3.17	Memory[vague] (agonists ↓); learning[vague] (agonists ↓); anxiety (agonists ↓); depression (agonists ↓); positive, negative, and cognitive symptoms of schizophrenia (partial agonists ↓); analgesia (agonists ↑); aggression (agonists ↓); dopamine release in the prefrontal cortex (agonists ↑); serotonin release and synthesis (agonists ↓)
5-HT1B	4.32	Vasoconstriction (agonists ↑); aggression (agonists ↓); bone mass (↓). Serotonin autoreceptor.
5-HT1D	5.03	Vasoconstriction (agonists ↑)
5-HT1E	7.53
5-HT1F	10
5-HT2 receptor family signals via Gq activation of phospholipase C.
5-HT2A	11.55	Psychedelia (agonists ↑; antagonists ↑); depression (agonists & antagonists ↓); anxiety (antagonists ↓); positive and negative symptoms of schizophrenia (antagonists ↓); norepinephrine release from the locus coeruleus (antagonists ↑); glutamate release in the prefrontal cortex
5-HT2B	8.71	Cardiovascular functioning (agonists increase risk of pulmonary hypertension), empathy (via the spindle neurons or Von Economo neurons[23])
5-HT2C	5.02	Dopamine release into the mesocorticolimbic pathway (agonists ↓); acetylcholine release in the prefrontal cortex (agonists ↑); appetite (agonists ↓); antipsychotic effects (agonists ↑); antidepressant effects (agonists & antagonists ↑)
Other 5-HT receptors
5-HT3	?	Emesis (agonists ↑); anxiolysis (antagonists ↑)
5-HT4	125.89	Movement of food across the GI tract (agonists ↑); memory & learning (agonists ↑); antidepressant effects (agonists ↑). Signalling viaGαs activation of adenylyl cyclase.
5-HT5A	251.2	Memory consolidation.[24] Signals via Gi/o inhibition of adenylyl cyclase
5-HT6	98.41	Cognition (antagonists ↑); antidepressant effects (agonists & antagonists ↑). Gs signalling via activating adenylyl cyclase.
5-HT7	8.11	Cognition (antagonists ↑); antidepressant effects (antagonists ↑). Acts by Gs signalling via activating adenylyl cyclase.